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Research Group Audebert

Neurology with a Focus on Stroke

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Prof. Heinrich Audebert, MD

Head of Research Group Audebert (Neurology with a Focus on Stroke)

CBF: Campus Benjamin Franklin

Prof. Heinrich Audebert, MD

Profile

Heinrich Audebert is a neurologist with a focus on neurovascular research. In the Department of Neurology and Experimental Neurology, he heads the Neurological Department at Campus Benjamin Franklin. His major scientific interest is the implementation and evaluation of new therapeutic concepts in stroke care. He is therefore involved in scientific projects dealing with pre-hospital stroke care, post-stroke inflammation, telemedicine and secondary prevention.

List of publications

Selected publications

Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin.
Ebinger M, Siegerink B, Kunz A, Wendt M, Weber JE, Schwabauer E, Geisler F, Freitag E, Lange J, Behrens J, Erdur H, Ganeshan R, Liman T, Scheitz JF, Schlemm L, Harmel P, Zieschang K, Lorenz-Meyer I, Napierkowski I, Waldschmidt C, Nolte CH, Grittner U, Wiener E, Bohner G, Nabavi DG, Schmehl I, Ekkernkamp A, Jungehulsing GJ, Mackert BM, Hartmann A, Rohmann JL, Endres M, Audebert HJ.
JAMA. 2021 Feb 2;325(5):454-466. doi: 10.1001/jama.2020.26345.
PMID: 33528537

A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial.
Ahmadi M, Laumeier I, Ihl T, Steinicke M, Ferse C, Endres M, Grau A, Hastrup S, Poppert H, Palm F, Schoene M, Seifert CL, Kandil FI, Weber JE, von Weitzel-Mudersbach P, Wimmer MLJ, Algra A, Amarenco P, Greving JP, Busse O, Köhler F, Marx P, Audebert HJ.
Lancet Neurol. 2020 Jan;19(1):49-60. doi: 10.1016/S1474-4422(19)30369-2. Epub 2019 Nov 7.
PMID: 31708447

Functional outcomes of pre-hospital stroke thrombolysis in a Mobile Stroke Treatment Unit compared to conventional care: an observational registry study.
Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Fiebach JB, Villringer K, Erdur H, Scheitz JF, Tütüncü S, Bollweg K, Grittner U, Kaczmarek S, Endres M, Nolte CH, Audebert HJ.
Lancet Neurol. 2016 Sep;15(10):1035-43. doi: 10.1016/S1474-4422(16)30129-6.
PMID:27430529

Cost-effectiveness estimate of prehospital thrombolysis: Results of the PHANTOM-S Study.
Gyrd-Hansen D, Olsen KR, Bollweg K, Kronborg C, Ebinger M, Audebert HJ.
Neurology. 2015 Mar 17;84(11):1090-7. doi: 10.1212/WNL.0000000000001366.
PMID:25672925

Improved Prehospital Triage of Patients With Stroke in a Specialized Stroke Ambulance: Results of the Pre-Hospital Acute Neurological Therapy and Optimization of Medical Care in Stroke Study.
Wendt M, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber JE, Winter B, Koch PM, Freitag E, Reich J, Schremmer D, Audebert HJ; STEMO Consortium.
Stroke. 2015 Mar;46(3):740-5. doi: 10.1161/STROKEAHA.114.008159.
PMID:25634000

Effects of Golden Hour Thrombolysis A Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) Substudy.
Ebinger M, Kunz A, Wendt M, Rozanski M, Winter B, Waldschmidt C, Weber J, Villringer K, Fiebach JB, Audebert HJ.
JAMA Neurol. 2015 Jan;72(1):25-30. doi: 10.1001/jamaneurol.2014.3188.
PMID:25402214

Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial.
Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ; STEMO Consortium.
JAMA. 2014 Apr 23-30;311(16):1622-31. doi: 10.1001/jama.2014.2850.
PMID:24756512

Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial Doehner W, Schenkel J, Anker SD, Springer J, Audebert HJ.
Eur Heart J. 2013 Jan;34(4):268-77. doi: 10.1093/eurheartj/ehs340. Epub 2012 Oct 16.
PMID: 23076781.

Long-term effects of specialized stroke care with telemedicine support in community hospitals on behalf of the Telemedical Project for Integrative Stroke Care (TEMPiS)
Audebert HJ, Schultes K, Tietz V, Heuschmann PU, Bogdahn U, Haberl RL, Schenkel J
Stroke. 2009 Mar;40(3):902-8. doi: 10.1161/STROKEAHA.108.529255. Epub 2008 Nov 20.
PMID: 19023095

Effects of the implementation of a telemedical stroke network: the Telemedic Pilot Project for Integrative Stroke Care (TEMPiS) in Bavaria, Germany
Audebert HJ, Schenkel J, Heuschmann PU, Bogdahn U, Haberl RL
Lancet Neurol. 2006 Sep;5(9):742-8. doi: 10.1016/S1474-4422(06)70527-0.
PMID: 16914402.

Impetus

Stroke is a medical emergency: after occlusion of the supplying arterial blood vessels, brain cells begin to die after just a few minutes. For treatment of ischemic stroke, intravenous thrombolysis and catheter-assisted mechanical thrombectomy are among the most effective treatment options, making it possible to reopen occluded vessels. Applying this therapy within a short time window can effectively protect patients against permanent limitations and disabilities.

However, delays in acute stroke care reduce treatment effects. Due to late emergency calls, loss of time during ambulance services, handovers during hospital admission as well as during diagnostic work-ups patients often arrive a stroke ready hospital hours after symptoms onset. Sometimes, thrombolysis and thrombectomy treatment are even no longer applicable.

Our projects aim to accelerate and improve the care of patients with strokes and other neurological emergency diseases in Berlin and the surrounding rural areas. Together with the Berlin fire brigade, we developed a query algorithm for stroke identification. Applying this algorithm, more than half of the acute stroke patients can be identified during emergency calls and ideally can be given targeted care. As shown in recent studies in Berlin and the USA, patients who are cared for by specialized Mobile Stroke Units (“MSU” or “STEMO” for Stroke-Einsatz-Mobil) have better chances to survive without long-term disability.

As part of the TeleNeurology ANNOTeM network with numerous consortium partners, we not only treat acute stroke emergencies but also other neurological emergencies such as epileptic seizures, spinal cord injuries or meningitis. Thanks to the networking of community based hospitals in Brandenburg, Mecklenburg-Western Pomerania and Saxony-Anhalt with tertiary care hospitals in Berlin and Greifswald, patients benefit from both local care and neurological treatment according to the highest scientific standards.

Most important projects

ANNOTeM

ANNOTeM stands for Acute Neurological Network in Northeast Germany with TeleMedicine support.
Implementation of a large TeleNeurology network in the states of Brandenburg and Mecklenburg-Vorpommern in order to improve acute neurological care in underserved areas.
More information/project description
 

B_PROUD - Berlin Pre-hospital Or Usual Delivery of stroke care project

The objective of the B_PROUD trial B_PROUD (Berlin Pre-hospital Or Usual Delivery of stroke care project) is to show improved functional outcomes after deployment of the Stroke Emergency Mobile (STEMO) compared to regular care.
More information/project description
 

INSPiRE-TMS

INSPiRE-TMS stands for Intensified Secondary Prevention intending a Reduction of vascular re-events in patients with TIA or Minor Stroke). Implementation of a supported secondary prevention program in patients with minor stroke or TIA and evaluation in a randomized controlled trial.
More information/project description
 

STEMO – Stroke Emergency Mobile

The STroke Emergency MObile (STEMO), a specialized ambulance vehicle, equipped with a computed tomography (CT) scanner, point of care laboratory devices and staffed with a trained team of specialists in acute stroke care (one neurologist, one paramedic and one radiology assistant) is available for prehospital thrombolysis of patients with acute ischemic stroke in Berlin, Germany.
More information/project description
 

ULTRAFAST

Ultra-early multimodal stroke diagnostics for the emergency medical services.
More information/project description