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Alte Nervenklinik Campus Charité Mitte

Research Group Mergenthaler

Experimental Neurology

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PD Dr. med. Philipp Mergenthaler

Head of Research Group Mergenthaler (Experimental Neurology)

CCM: Campus Charité Mitte

Portrait of PD Dr. med. Philipp Mergenthaler

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Selected publications

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.
Mergenthaler P*, Hariharan S*, Pemberton JM, Lourenco C, Penn LZ, Andrews DW. PLoS Comput Biol. 2021 Feb 22;17(2):e1008630. doi: 10.1371/journal.pcbi.1008630.
PMID: 33617523; PMCID: PMC7932518; Code:

FRC-QE: A robust and comparable 3D microscopy image quality metric for cleared organoids.
Preusser F, Dos Santos N, Contzen J, Stachelscheid H, Costa ÉT, Mergenthaler P*, Preibisch S*. Bioinformatics. 2021 Mar 8:btab160. doi: 10.1093/bioinformatics/btab160. Epub ahead of print.
PMID: 33693580.

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Niu X*, Brahmbhatt H*, Mergenthaler P*, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5. doi: 10.1016/j.chembiol.2017.03.011. Epub 2017 Apr 6.
PMID: 28392146; PMCID: PMC6508953.

Sugar for the brain: the role of glucose in physiological and pathological brain function.
Mergenthaler P, Lindauer U, Dienel GA, Meisel A. Trends Neurosci. 2013 Oct;36(10):587-97. doi: 10.1016/j.tins.2013.07.001. Epub 2013 Aug 20.
PMID: 23968694; PMCID: PMC3900881.

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.
Mergenthaler P, Kahl A, Kamitz A, van Laak V, Stohlmann K, Thomsen S, Klawitter H, Przesdzing I, Neeb L, Freyer D, Priller J, Collins TJ, Megow D, Dirnagl U, Andrews DW, Meisel A. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1518-23. doi: 10.1073/pnas.1108225109. Epub 2012 Jan 10.
PMID: 22233811; PMCID: PMC3277118.