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Head of CSB Trial Team; Head of Research Group Nolte (Heart-Brain Interaction)
CBF: Campus Benjamin Franklin
Profile
Christian Nolte is the Senior Physician of the Department of Neurology with Experimental Neurology and heads both the Clinical Studies Team (CSB Trial Team) at the Centre for Stroke Research Berlin (CSB) and (in collaboration) the certified, transregional Stroke Unit at Charité Campus Benjamin Franklin (CBF). He manages the Thrombolysis and Endovascular Recanalisation Register of the CBF. His main scientific interest is the interaction between heart and brain and the treatment of acute ischemic strokes.
Selected publications
Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin.
Ebinger M, Siegerink B, Kunz A, Wendt M, Weber JE, Schwabauer E, Geisler F, Freitag E, Lange J, Behrens J, Erdur H, Ganeshan R, Liman T, Scheitz JF, Schlemm L, Harmel P, Zieschang K, Lorenz-Meyer I, Napierkowski I, Waldschmidt C, Nolte CH, Grittner U, Wiener E, Bohner G, Nabavi DG, Schmehl I, Ekkernkamp A, Jungehulsing GJ, Mackert BM, Hartmann A, Rohmann JL, Endres M, Audebert HJ.
JAMA. 2021 Feb 2;325(5):454-466.
How do treatment times impact on functional outcome in stroke patients undergoing thrombectomy in Germany? Results from the German Stroke Registry.
Herm J, Schlemm L, Siebert E, Bohner G, Alegiani AC, Petzold GC, Pfeilschifter W, Tiedt S, Kellert L, Endres M, Nolte CH.
Int J Stroke. 2021 Jan 20:1747493020985260. doi: 10.1177/1747493020985260
PRediction of acute coronary syndrome in acute ischemic StrokE (PRAISE) - protocol of a prospective, multicenter trial with central reading and predefined endpoints.
Nolte CH, von Rennenberg R, Litmeier S, Scheitz JF, Leistner DM, Blankenberg S, Dichgans M, Katus H, Petzold GC, Pieske B, Regitz-Zagrosek V, Wegscheider K, Zeiher AM, Landmesser U, Endres M.
BMC Neurol. 2020 Aug 27;20(1):318. doi: 10.1186/s12883-020-01903-0
High-Sensitivity Cardiac Troponin T for Risk Stratification in Patients With Embolic Stroke of Undetermined Source.
Scheitz JF, Pare G, Pearce LA, Mundl H, Peacock WF, Czlonkowska A, Sharma M, Nolte CH, Shoamanesh A, Berkowitz SD, Krahn T, Endres M; NAVIGATE-ESUS Biomarker Working Group. Stroke. 2020 Aug;51(8):2386-2394.
Effects of Prehospital Thrombolysis in Stroke Patients With Prestroke Dependency.
Nolte CH, Ebinger M, Scheitz JF, Kunz A, Erdur H, Geisler F, Braemswig TB, Rozanski M, Weber JE, Wendt M, Zieschang K, Fiebach JB, Villringer K, Grittner U, Kaczmarek S, Endres M, Audebert HJ.
Stroke. 2018 Mar;49(3):646-651.
PMID:29459395
Stroke-heart syndrome: clinical presentation and underlying mechanisms.
Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M.
Lancet Neurol. 2018 Dec;17(12):1109-1120. doi: 10.1016/S1474-4422(18)30336-3. Epub 2018 Oct 26. Review.
PMID:30509695
Effects of Ultraearly Intravenous Thrombolysis on Outcomes in Ischemic Stroke: The STEMO (Stroke Emergency Mobile) Group.
Kunz A, Nolte CH, Erdur H, Fiebach JB, Geisler F, Rozanski M, Scheitz JF, Villringer K, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Grittner U, Kaczmarek S, Endres M, Ebinger M, Audebert HJ.
Circulation. 2017 May 2;135(18):1765-1767
PMID:28461420
Stroke in right dorsal anterior insular cortex Is related to myocardial injury.
Krause T, Werner K, Fiebach JB, Villringer K, Piper SK, Haeusler KG, Endres M, Scheitz JF, Nolte CH.
Ann Neurol. 2017 Apr;81(4):502-511.
PMID:28253544
Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients - results from VISTA.
Nolte CH, Erdur H, Grittner U, Schneider A, Piper SK, Scheitz JF, Wellwood I, Bath PM, Diener HC, Lees KR, Endres M; VISTA collaborators.Eur J Neurol. 2016 Dec;23(12):1750-1756. doi: 10.1111/ene.13115.
PMID:27516056
Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study.
Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Fiebach JB, Villringer K, Erdur H, Scheitz JF, Tütüncü S, Bollweg K, Grittner U, Kaczmarek S, Endres M, Nolte CH, Audebert HJ.
Lancet Neurol. 2016 Sep;15(10):1035-43. doi: 10.1016/S1474-4422(16)30129-6.
PMID:27430529
Statins and risk of poststroke hemorrhagic complications.
Scheitz JF, MacIsaac RL, Abdul-Rahim AH, Siegerink B, Bath PM, Endres M, Lees KR, Nolte CH; VISTA collaboration.
Neurology. 2016 Apr 26;86(17):1590-6. doi: 10.1212/WNL.0000000000002606.
PMID:27016519
Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study.
Mochmann HC, Scheitz JF, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M, Witzenbichler B, Nolte CH; TRELAS Study Group.
Circulation. 2016 Mar 29;133(13):1264-71. doi: 10.1161/CIRCULATIONAHA.115.018547.
PMID:26933082
Impetus
Numerous recommendations for stroke treatments are based on the results of randomised controlled trials (RCTs). Patients included in those trials do not necessarily mirror the characteristics of typical everyday stroke patients, but meet specific inclusion criteria. We investigate stroke treatments "in real life", outside of RCTs. We examine what factors influence the treatment process in everyday practice. We also identify, on the one hand, decisive factors for a good prognosis and, on the other hand, question established treatment practices. We only became aware of many prognostic factors thanks to new diagnostic test procedures (e.g. MRI), which were partially still unknown, when specific RCTs were carried out, e.g. cerebral microbleeds, cavernomas or the so-called "hyperintense vessel sign". Several of our works are cited in the current guidelines for stroke treatment of the American Heart Association (AHA).
Most important projects
HEBRAS – Heart and Brain interaction in Acute Stroke
This prospective observational study is examining whether an enhanced MRI investigation leads to a significant increase of the findings regarding the cause of stroke.
More information/project description
PRAISE
The primary goal of the "PRAISE" ("Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke") study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients.
More information/project description
Cooperations and research partners
- Prof. Guillaume Turc, Centre hospitalier Sainte-Anne, Paris, France
- Prof. Dr. Simon Jung & Dr. David Seiffge, Inselspital Bern, Switzerland
- Prof. David Werring, London, UK
- Prof. Stefan Engelter & PD Dr. Henrik Gensicke, Universitätsspital Basel, Switzerland
- Prof. Susanne Wegener, Zurich, Switzerland