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Research in the Neuroepidemiology Group focuses on the development and application of modern epidemiological and statistical methods in the context of stroke and other neurological diseases. Our research projects focus on the application of causal inference methods and clinical risk prediction modeling, as well as methods work at the intersection of these domains. Our diverse breadth of applied projects in medicine and population health illustrate how methodological projects often transcend traditional discipline boundaries. Currently, our clinical focus areas include headache disorders and neurovascular outcomes, hypercoagulability, short- and long-term outcomes after stroke, sex- and gender aspects in neurovascular disease, and the analysis of neurological disease registry data.
The Neuroepidemiology Group further contributes methodological expertise to studies at the Center for Stroke Research as well as to numerous national and international collaborations. Our group values reproducibility, transparency, and quality of methodological reporting in research. We actively promote the use of modern causal inference tools, such as directed acyclic graphs, in applied research. We advocate for these aspects within Charité through our involvement in training Master’s and doctoral students as well as early-career researchers. For example, our group members are active in the "Health Data Sciences" PhD Program and the "Peerspectives" peer-review training initiative (in collaboration with the BMJ). Outreach activities, such as the "Berlin Epidemiological Methods Colloquium" (BEMC), promote continuing education on these topics and serve to connect the Berlin community of methodological enthusiasts at-large.
We closely collaborate with the "Causal methOds and NeuroVascular Epidemiology Research Group" (CONVERGE) at the Institute of Public Health at Charité and with Bob Siegerink, PhD, (former CSB group leader) at the Department of Clinical Epidemiology at the Leiden University Medical Center.
- Jessica L. Rohmann
Leader Research Group Rohmann/Neuroepidemiology, Head of CSB Epidemiology
- Marco Piccininni
- Nadja Wülk
- Fernando Urrutia González
- Emma S. Lieske
- Rodrigo Huerta Gutiérrez de Velasco
- Meghan Forrest
- Chris Buchholz
- Jakob Beilstein
- Tobias Kurth
Institute of Public Health, Charité – Universitätsmedizin Berlin
Former team members
- Ana Sofia Oliveira Gonçalves
- Saskia Lange
Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke.
Rohmann JL, Huo S, Sperber PS, Piper SK, Rosendaal FR, Heuschmann PU, et al.
J Thromb Haemost. 2020 Sep 16.
Directed acyclic graphs and causal thinking in clinical risk prediction modeling.
Piccininni M, Konigorski S, Rohmann JL, Kurth T.
BMC Med Res Methodol. 2020 Jul 2;20(1):179.
Parallel pandemic: The crush of covid-19 publications tests the capacity of scientific publishing.
Kurth T, Piccininni M, Loder EW, Rohmann JL.
BMJ Opinion. 2020 May 26.
Blockchain-based innovations for population-based registries for rare neurodegenerative diseases.
Piccininni M, Rohmann JL, Logroscino G, Kurth T.
Frontiers in Blockchain. 2020;3:20.
Performance of risk prediction scores for cardiovascular mortality in older persons: External validation of the SCORE OP and appraisal.
Piccininni M*, Rohmann JL*, Huscher D, Mielke N, Ebert N, Logroscino G, et al.
PLoS One. 2020 Apr 9;15(4):e0231097.
PMID: 32271825 (*shared authorship)
Migraine, headache, and mortality in women: a cohort study.
Rohmann JL, Rist PM, Buring JE, Kurth T.
J Headache Pain. 2020 Mar 17; 21(1): 27.
Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B).
Sperber PS, Siegerink B, Huo S, Rohmann JL, Piper SK, Prüss H, et al.
Stroke. 2019 Sep 17;STROKEAHA119026100.
Genetic determinants of activity and antigen levels of contact system factors.
Rohmann JL, de Haan HG, Algra A, Vossen CY, Rosendaal FR, Siegerink B.
J Thromb Haemost. 2019 Jan;17(1):157–68.
B-SPATIAL – Registry for quality assurance in stroke therapyin Berlin
Stroke is a leading cause of death and disability. However, improving diagnostics and treatments such as thrombolysis and endovascular therapy have substantially reduced the burden of this disease. The "B-SPATIAL" registry ("Berlin-Specific Acute Therapy in Ischemic or hemorrhagic stroke with Long-term follow-up") captures the processes during acute care of stroke patients and provides a unique opportunity to assess their effects on functional outcome.
"WISE-DAG" ("Wisdom of Stroke Experts translated into Directed Acyclic Graphs") is a study to aggregate the expert causal knowledge of clinicians and researchers about stroke-related processes.
More information/project description