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Research Group Scheitz

Research Group Integrative Cardio-Neurology

Heart-Brain Interaction in Stroke

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Prof. Jan F. Scheitz, MD

Head of Research Group Integrative Cardio-Neurology (Heart-Brain Interaction in Stroke)

CBF: Campus Benjamin Franklin

Portrait of Prof. Jan F. Scheitz, MD

Profile

Jan Scheitz is a clinician scientist and senior physician at the Charité Department of Neurology at the Benjamin Franklin Campus (CBF). His main scientific interest is to explore the interaction between brain and heart. He is especially involved in projects about the pathomechanisms and prognostic significance of post-stroke cardiac complications (‘stroke-heart syndrome’). Prof. Scheitz takes an active role in the “Heart&Brain Task Force” of the World Stroke Organization. #brainheart

Selected publications

Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury: JACC State-of-the-Art Review
Sposato LA, Hilz MJ, Aspberg S, Murthy SB, Bahit MC, Hsieh CY, Sheppard MN, Scheitz JF, World Stroke Organisation Brain & Heart Task Force. 2020;76:2768-2785.
PMID: 33272372

Stroke-heart syndrome: clinical presentation and underlying mechanisms.
Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M.
Lancet Neurol. 2018 Dec;17(12):1109-1120. doi: 10.1016/S1474-4422(18)30336-3. Epub 2018 Oct 26. Review.
PMID: 30509695

Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-Analysis.
Broersen LHA, Stengl H, Nolte CH, Westermann D, Endres M, Siegerink B, Scheitz JF.
Stroke. 2020 Feb 10:STROKEAHA119028323. doi: 10.1161/STROKEAHA.119.028323. [Epub ahead of print]
PMID: 32078461

Neurological update: use of cardiac troponin in patients with stroke.
Scheitz JF, Stengl H, Nolte CH, Landmesser U, Endres M.
J Neurol. 2020 Dec 29. Doi:10.1007/s00415-020-10349-w
PMID: 33372247

Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study.
Mochmann HC*, Scheitz JF*, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M*, Witzenbichler B*, Nolte CH*; TRELAS Study Group.
Circulation. 2016 Mar 29;133(13):1264-71. doi: 10.1161/CIRCULATIONAHA.115.018547. Epub 2016 Mar 1.
PMID: 26933082
* contributed equally

High-sensitivity cardiac troponin T and severity of cerebral white matter lesions in patients with acute ischemic stroke.
von Rennenberg R, Siegerink B, Ganeshan R, Villringer K, Doehner W, Audebert HJ, Endres M, Nolte CH*, Scheitz JF*.
J Neurol. 2019 Jan;266(1):37-45. doi: 10.1007/s00415-018-9085-3. Epub 2018 Oct 11.
PMID: 30311052
* contributed equally

Insular cortex lesions, cardiac troponin, and detection of previously unknown atrial fibrillation in acute ischemic stroke: insights from the troponin elevation in acute ischemic stroke study.
Scheitz JF, Erdur H, Haeusler KG, Audebert HJ, Roser M, Laufs U, Endres M, Nolte CH.
Stroke. 2015 May;46(5):1196-201. doi: 10.1161/STROKEAHA.115.008681. Epub 2015 Apr 2.
PMID: 25835563 

Clinical Selection Strategies to Identify Ischemic Stroke Patients With Large Anterior Vessel Occlusion: Results From SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry).
Scheitz JF*, Abdul-Rahim AH*, MacIsaac RL, Cooray C, Sucharew H, Kleindorfer D, Khatri P, Broderick JP, Audebert HJ, Ahmed N, Wahlgren N, Endres M, Nolte CH*, Lees KR*; SITS Scientific Committee.
Stroke. 2017 Feb;48(2):290-297. doi: 10.1161/STROKEAHA.116.014431. Epub 2017 Jan 13. Erratum in: Stroke. 2017 Mar;48(3):e95.
PMID: 28087804
* contributed equally

Impetus

Acute myocardial injury (high-sensitivity troponin, hs-cTn) and heart failure and cardiac arrhythmia are observed in approximately 20 % of patients. There is growing evidence that these changes can be due to stroke-related disturbance of normal autonomic control of the heart ("stroke-heart syndrome"). However, many of these cases are difficult to distinguish from an acute coronary syndrome in everyday clinical practice. In our projects, we aim to improve clinical algorithms for the treatment of stroke patients with acute myocardial injury and identify potential therapeutic targets. We also focus on individual risk prediction of stroke recurrence, cognitive disorders and atrial fibrillation using cardiac biomarkers, and are interested in takotsubo syndrome after neurological disorders.

Most important project

CORONA-IS

The primary objective of the CORONA-IS study (CardiOmyocyte injuRy follOwing Acute Ischemic Stroke) is to explore the developmental mechanisms of stroke-associated, acute myocardial damage in an interdisciplinary approach.
More information/project description

Team

Prof. Jan F. Scheitz, MD

Head of Research Group Integrative Cardio-Neurology (Heart-Brain Interaction in Stroke)

Portrait of Prof. Jan F. Scheitz, MD
Ramanan Ganeshan, MD

Research Group Integrative Cardio-Neurology

Portrait of Ramanan Ganeshan, MD
Helena Stengl, MD

Research Group Integrative Cardio-Neurology

Portrait of Helena Stengl, MD

Further team members

  • Simon Hellwig, MD
  • Markus Klammer
  • Jess Lim (PhD student)
  • Sophie Böhme (PhD student)
     
  • Kristin Simon (study nurse)
     
  • Leonie Broersen, PhD (former team member)